{"id":10294,"date":"2018-06-08T17:59:18","date_gmt":"2018-06-08T15:59:18","guid":{"rendered":"https:\/\/okomeds.com\/?p=10294\/"},"modified":"2020-08-31T20:15:30","modified_gmt":"2020-08-31T18:15:30","slug":"new-discoveries-can-speed-clinical-translation","status":"publish","type":"post","link":"https:\/\/okomeds.com\/es\/new-discoveries-can-speed-clinical-translation\/","title":{"rendered":"New discoveries can speed clinical translation"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Clinical translation can speed the knowledge that new discoveries imply and it can even serve to increase the research related to the discovery and its application. As an example, we are going to pick a recent discovery concerning stem cell therapies. We are referring to a new more efficient approach that consists on reprogramming diseased skin cells into stem cells for any patient.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With a precedent in 2006, the main importance of this discovery is that as regenerative medicine, it implies unlimited source of patient-specific cells suitable for transplantation. Therefore, Okomeds, as a life-science translation provider, and CROs translation provider, is interested in echoing this interesting discovery that has already arisen much interest among the medical community.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is also important to point out that in the referred to case, the immature embryonic stem cells that are been reprogrammed, can be grown in or outside the body, transplanted or used for research and genetically manipulated. However, the technology, although promising is not yet well enough developed to guarantee safety for clinical applications.<\/span><\/p>\n<p>&nbsp;<\/p>\n\r\n        <a href=\"https:\/\/twitter.com\/intent\/tweet?text=CROs role is crucial when there is a shift from the laboratory to clinical trials&url=&via=okomeds\" class=\"retweet-okodia\" >CROs role is crucial when there is a shift from the laboratory to clinical trials <div class=\"retwitear-ok\" style=\"text-align: right;   font-size: 10px; padding-right: 43px;\">Tweet!<\/div><\/a>\r\n        <script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0];if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=\"\/\/platform.twitter.com\/widgets.js\";fjs.parentNode.insertBefore(js,fjs);}}(document,\"script\",\"twitter-wjs\");<\/script>\n<p>&nbsp;<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Alternar tabla de contenidos\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/okomeds.com\/es\/new-discoveries-can-speed-clinical-translation\/#From_new_discoveries_to_clinical_translation\" >From new discoveries to clinical translation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/okomeds.com\/es\/new-discoveries-can-speed-clinical-translation\/#Clinical_translation_holds_great_potential_for_the_development\" >Clinical translation holds great potential for the development<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"From_new_discoveries_to_clinical_translation\"><\/span><b>From new discoveries to clinical translation<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nevertheless this new discovery means that simple manipulations of the RNA molecules could affect the efficiency of reprogramming. Specifically, manipulations of dosing of the RNA molecules or of timing. Therefore, improving reprogramming efficiency, especially if the process is done at a reduced cell density, due to the direct correlation between the rate of cell division and the efficiency of reprogramming.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As CROs are increasingly involved in <a href=\"https:\/\/okomeds.com\/clinical-research-translation-news-april-cro-special\/\" target=\"_blank\" rel=\"noopener noreferrer\">clinical research<\/a> and concentrate wide expertise in clinical design, therapeutic areas, geographical areas, or contract research regulations, they are increasingly considered strategic partners to pharmaceutical, biopharmaceutical, or similar companies. Even Universities can act as CROs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In this sense, CROs role is crucial when there is a shift from the laboratory to clinical trials. And this is the current stage of the recent discovery we used as an example. Once the shift is produced, translation services also achieve an important protagonism, as clinical trials need clinical translation.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10297 size-full\" src=\"https:\/\/okomeds.com\/wp-content\/uploads\/2018\/06\/POSTS-LINKEDIN-Y-GOOGLE-PLUS-1.png\" alt=\"New discoveries can speed clinical translation 2\" width=\"500\" height=\"275\" srcset=\"https:\/\/okomeds.com\/wp-content\/uploads\/2018\/06\/POSTS-LINKEDIN-Y-GOOGLE-PLUS-1.png 500w, https:\/\/okomeds.com\/wp-content\/uploads\/2018\/06\/POSTS-LINKEDIN-Y-GOOGLE-PLUS-1-300x165.png 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Clinical_translation_holds_great_potential_for_the_development\"><\/span><b>Clinical translation holds great potential for the development<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both the trials and their translation hold great potential for the development, especially when we are talking of a discovery as the one of the example, that can mean new corrective stem cell-based therapies that can be applied for currently incurable diseases. At the same time, clinical trials and clinical translation can help setting the standards for future therapies for other diseases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Being able to provide <a href=\"https:\/\/okomeds.com\/the-two-steps-of-translation-of-new-medical-information\/\" target=\"_blank\" rel=\"noopener noreferrer\">the right information <\/a>to the right people, through the right channel and at the right time, can be key for successful communication of any discovery and for the clinical trials that must follow. Potential delays and bottlenecks can be avoided by the adequate intervention of specialized translation services, reducing the number of intermediaries, improving comprehension and minimizing the level of noise.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quality assurance is a needed goal. And, as regards <a href=\"https:\/\/okomeds.com\/ensuring-accurate-medical-translations-for-contract-research-organizations-cros\/\" target=\"_blank\" rel=\"noopener noreferrer\">translations for CROs<\/a>, it involves planned and systematic actions to ensure performed and generated data are correctly documented and reported in compliance with the regulations in force. In this sense, we must highlight that trusted clinical translation and translation services shall be a part of the implementation of a quality management system for any medical product development.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To conclude, we would like to say that since it takes years to develop new drugs or products and clinical trials can be unpredictable, a strategic partnership between<a href=\"https:\/\/okomeds.com\/keys-to-success-between-cros-and-medical-translation-agencies\/\" target=\"_blank\" rel=\"noopener noreferrer\"> CROs and Medical Translation Services<\/a>, and also between Sponsors and CROs, may not only be useful in times of crisis, but also in the long term. This means that choosing the right partner is essential, not only to avoid relationship pitfalls, but also to guarantee effective clinical translation, communication and consistency.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clinical translation can speed the knowledge that new discoveries imply and it can even serve to increase the research related to the discovery and its application. As an example, we are going to pick a recent discovery concerning stem cell therapies. We are referring to&#8230;<\/p>\n","protected":false},"author":1,"featured_media":10296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,280],"tags":[300,290,281,192,294,295,289,191,286,282,292,301,288,297,239,287,299,298,296,285,284,283,243,302,293,291],"class_list":["post-10294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-research","category-translation-for-cros","tag-biopharmaceutical","tag-clinical-design","tag-clinical-translation","tag-clinical-trials","tag-communication","tag-consistency","tag-contract-research-regulations","tag-cros","tag-cros-translation","tag-discoveries","tag-geographical-areas","tag-incurable-diseases","tag-laboratory","tag-medical-product","tag-medical-translation-services","tag-okomeds","tag-pharmaceutical","tag-product-development","tag-quality-management-system","tag-reprogramming","tag-rna-molecules","tag-skin-cells","tag-sponsors","tag-stem-cell-based-therapies","tag-strategic-partnership","tag-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New discoveries can speed clinical translation - Okomeds<\/title>\n<meta name=\"description\" content=\"Clinical translation can speed the knowledge that new discoveries imply and it can even serve to increase the research related to the discovery and its application. 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